> R. Starosta,  R.F.M. de Almeida  (2020) Luminescence properties of the antifungal agent ketoconazole and its diphenylphosphane derivatives. J. Lumin. 220, 116956. DOI: 10.1016/j.jlumin.2019.116956.

> C. Sousa, F.C. Santos, A. Bento-Oliveira, B. Mestre, L.C. Silva, R.F.M. de Almeida (2020) Chapter 14: Biophysical analysis of lipid domains in mammalian and yeast membranes by fluorescence spectroscopy. In Lipid rafts – Methods of isolation, visualization, and functional analysis (E. Bieberich, ed.), MiMB, Humana Press – Springer Nature.

> A.E. Ventura, T.C.B. Santos, J.T. Marquês, R.F.M. de Almeida, L.C. Silva (2020) Chapter 13: Biophysical analysis of lipid domains by fluorescence microscopy. In Lipid rafts – Methods of isolation, visualization, and functional analysis (E. Bieberich, ed.), MiMB, Humana Press – Springer Nature.

> R.F.M. de Almeida, F.C. Santos, A. Bento-Oliveira, J.T. Marquês (2020) Membranas em ação? Nitrogénio em rede é campeão! In Os Elementos em Ciências - uma viagem pela Tabela Periódica”(A. Mourato, A.P. Carvalho, F. Martins, T. Pamplona, Eds), in press. ISBN 978-972-9348-21-1 (paperback); 978-972-9348-22-8 (e-book), Edições FCUL.

> R.F.M. de Almeida, F.C. Santos, K. Marycz, M. Alicka, A. Krasowska, J. Suchodolski, J.J. Panek, A. Jezierska, R. Starosta* (2019) New diphenylphosphane derivatives of ketoconazole are promising antifungal agents. Sci. Rep. 9, 16214. DOI:10.1038/s41598-019-52525-7.

> A. Granada-Flor, C. Sousa, H. A. L. Filipe, M. S. C. S. Santos, R. F. M. de Almeida (2019) Quercetin dual interaction at the membrane level. Chem. Comm. 55, 1750 – 1753. DOI: 10.1039/c8cc09656b.

> F. Pires, V. P. N. Geraldo, B. Rodrigues, A. Granada-Flor, R. F. M. de Almeida, O. N. Oliveira, B. L. Victor, M. Machuqueiro, M. Raposo (2019) Evaluation of EGCG Loading Capacity in DMPC Membranes. Langmuir 35, 6771-6781. DOI: 10.1021/acs.langmuir.9b00372.

> B. Demoro, A. Bento-Oliveira, F. Marques, J. C. Pessoa, L. Otero, D. Gambino, R. F. M. de Almeida,  A. I. Tomaz (2019) Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity. Molecules 24, E2861.

> A.C. Carreira, T.C. Santos, M.A. Lone, E. Zupančič, E. Lloyd-Evans, R.F.M. de Almeida, T. Hornemann, L.C. Silva (2019) Mammalian sphingoid bases: Biophysical, physiological and pathological properties. Prog. Lipid Res. 75, 100988. DOI: 10.1016/j.plipres.2019.100995.

> A. A. Duarte, J. T. Marquês, F. Brasil, A. S. Viana, P. Tavares, M. Raposo (2019) In Situ AFM Imaging of Adsorption Kinetics of DPPG Liposomes: A Quantitative Analysis of Surface Roughness. Microsc. Microanal. 25,798-809. DOI: 10.1017/S1431927619000345.

>P. Vieira, M.Q. Miranda, I. Marques, S. Carvalho, Li-Jun Chen, E.N.W. Howe, C. Zhen, C.Y. Leung, M.J. Spooner, B. Morgado, O.A.B. da Cruz e Silva, C. Moiteiro*, P.A. Gale*, V. Félix* (2019) Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity. Chem. Eur. J. 26, 888-899. DOI: 10.1002/chem.201904255.

> J. T. Marquês, H. S. Marinho, R. F. M. de Almeida (2018) Sphingolipid hydroxylation in mammals, yeast and plants - An integrated view. Prog Lipid Res., 71: 18-42; DOI: 10.1016/j.plipres.2018.05.001.

> H. A. L.  Filipe, C. Sousa, J. T. Marquês, D. Vila-Viçosa, A. G. Flor, A. S. Viana, M. S. C. S.  Santos; M. Machuqueiro; R. F. M. de Almeida (2018) Differential targeting of membrane lipid domains by caffeic acid and its ester derivatives. Biol. Med., Vol. 115 (232-245); DOI: 10.1016/j.freeradbiomed.2017.12.002​.

> C. Dias, J. P. Pais, R. Nunes, M. Blázquez-Sánchez, J. T. Marquês, A. F. Almeida, P. Serra, N. M. Xavier, D. Vila-Viçosa, M. Machuqueiro, A. S. Viana, A. Martins, M. S. Santos, A. Pelerito, R. Dias, R. Tenreiro, M. C. Oliveira, M. Contino, N. A. Colabufo, R. F. M. de Almeida, A. P. Rauter (2018) Sugar-Based Bactericides Targeting Phosphatidylethanolamine-Enriched Membranes

Nature Commun. 9, 4857.

> R. F. M. de Almeida (2018) A route to understanding yeast cellular envelope - plasma membrane lipids interplaying in cell wall integrity.​  FEBS J. 285: 2402-2404; DOI: 10.1111/febs.14526.

> F. C. Santos, G. M. Lobo, A. S. Fernandes, A. Videira, R. F. M. de Almeida​ (2018)  Changes in the biophysical properties of the cell membrane are involved in the response of Neurospora crassa to staurosporine Front. Physiol. (in press); DOI: 10.3389/fphys.2018.01375.

> F. C. Santos, A. S. Fernandes, C. A. C. Antunes, F. P. Moreira, A. Videira, H. S. Marinho, R. F. M. de Almeida (2017) Reorganization of plasma membrane lipid domains during conidial germination. Biochem. Biophys. Acta - Mol. Cell Biol. Lipids, Vol. 1862 (156-166); DOI: 10.1016/j.bbalip.2016.10.011.

>A. C. Carreira, R. F. M. de Almeida, L. C. Silva (2017) Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties. Sci. Reports 7, Article number: 3949; DOI:10.1038/s41598-017-04125-6

>A. G. Santos, J. T. Marquês, A. C. Carreira, I. R. Castro, A. S. Viana, M.-P. Mingeot-Leclercq, R. F. M. de Almeida, L. C. Silva (2017) The molecular mechanism of Nystatin action is dependent on membrane biophysical properties and lipid composition. Phys. Chem. Chem. Phys., Vol. 19 (30078-30088); DOI: 10.1039/C7CP05353C.

> O. Domotor, R. F. M. de Almeida, L. Corte-Real, C. P. Matos, F. Marques, A. Matos, C. Real, T. Kiss, E.A. Enyedy, M.H. Garcia, A.I. Tomaz (2017) Studies on the mechanism of action of antitumor bis(aminophenolate) ruthenium(III) complexes. J. Inorg. Biochem, 168 (27-37); DOI: 10.1016/j.jinorgbio.2016.12.008.

> S. Alegre-Gómez, P. Sainz, M. F. Simões, P. Rijo, C. Moiteiro, A. González-Coloma, R. A. Martínez-Diaz (2017) Antiparasitic activity of diterpenoids against Trypanosoma cruzi. Planta Medica, Vol. 83 (306-311); DOI:10.1055/s-0042-115646.

> D. Cunha-Reis, R. F. M. de Almeida, J. A. Ribeiro, A. M. Sebastião (2017) VPAC1 and VPAC2 receptor opposed modulation of GABA release from hippocampal nerve terminals involves multiple signalling pathways. British J. Pharmacol., Vol. 174 (4725-4737); DOI: 10.1111/bph.14051.

> T. O. Paiva, I. Almeida, J. T. Marquês, W. Liu, Y. Niu, G. Jin, A. S. Viana (2017) Nanostructured interfaces with site-specific bioreceptors for immunosensing. Appl. Surf. Sci. 412, 455-463.

> T. O. Paiva, A. E. P. Bastos, J. T. Marquês, A. S. Viana, P. A. Lima, R. F. M. de Almeida (2016) m-cresol affects lipid bilayers in membrane models and living neurons. RSC Adv., 6, 105699-105712.

> J. M. S. Faria,  A. M. Rodrigues, I. Sena, C. Moiteiro, R. N. Bennett, M. Mota, A. C. Figueiredo (2016) Bioactivity of Ruta graveolens and Satureja montana essential oils on Solanum tuberosum hairy roots and S. tuberosum hairy roots with Meloidogyne chitwoodi co-cultures. J. Agr. Food Chem.; DOI: 10.1021/acs.jafc.6b03279.

> U. K. Komarnicka, R. Starosta, M. Płotek, R. F. M. de Almeida, M. Jeżowska-Bojczuk, A. Kyzioł (2016) Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode. Dalton Trans., 45, 5052-5063. DOI:10.1039/C5DT04011F.

> J. Benites, C. Moiteiro, A.C. Figueiredo, P. Rijo, M. Ganoza (2016) Chemical composition and antimicrobial activity of essential oil of peruvian Dalea strobilacea. Blacpma; Vol. 15 (6).

> J. T. Marquês, A. M. Cordeiro, A. S. Viana, A. Herrmann, H. S. Marinho, R. F. M. de Almeida (2015) Formation and properties of membrane ordered domains by phytoceramide: role of sphingoid base hydroxylation. Langmuir 31 (34), 9410-9421; DOI: 10.1021/acs.langmuir.5b02550.

> A. Bagulho, F. Vilas-Boas, A. Pena, C. Peneda, F. C. Santos, A. Jerónimo, R. F. M. de Almeida, C. Real (2015) The extracellular matrix modulates H2O2 degradation and redox signaling in endothelial cells. Redox Biol.; DOI: 10.1016/j.redox.2015.09.006​.

> I. Almeida, J. T. Marquês, W. Liu, Y. Niu, R. F. M. de Almeida, G. Jin, A. S. Viana (2015) Phospholipid/cholesterol/decanethiol mixtures for direct assembly of immunosensing interfaces. Colloids Surf. B: Biointerfaces,  136, 997-1003; doi:10.1016/j.colsurfb.2015.10.048​.

> J. M. S. Faria, I. Sena, C. Moiteiro, R. N. Bennett, M. Mota, C. Figueiredo (2015) Nematotoxic and phytotoxic activity of Satureja Montana and Ruta graveolens essential oils on Pinus pinaster shoot cultures an P. pinaster with Bursaphelenchus xylophilus in vitro co-cultures. Ind. Crop. Prod. 77, 59-65.

> D. K. Rocha, O. Matos, M. T. Nóvoa, A. C. Figueiredo, M. Delgado, C. Moiteiro (2015) Larvicidal Activity Against Aedes aegypti of Foeniculum vulgare Essential Oils from Portugal and Cape Verde. Nat. Prod. Commun. 10, 677-682.

> M. M. Santos, I. Marques, S. Carvalho, C. Moiteiro, V. Félix (2015) Recognition of bio-relevant dicarboxylate anions by an azacalix[2]arene[2]triazine derivative decorated with urea moieties. Org. Biomol. Chem. 13, 3070-3085; DOI: 10.1039/C4OB02283A.

> J. T. Marquês, C. A. C. Antunes, F. C. Santos, R. F. M. de Almeida (2015) Biomembrane Organization and Function: The Decisive Role of Ordered Lipid Domains in A. Iglic, C.  Kulkarni, M. Rappolt, eds.: Advances in Planar Lipid Bilayers and Liposomes, Vol 22, ADPLAN, UK: Academic Press,  pp 65-96; DOI:10.1016/bs.adplan.2015.06.002.

> D. Rocha, M. Novo, O. Matos, A. C. Figueiredo, M. Delgado,  M. D. Cabral, M. Liberato, C. Moiteiro (2015) Potencial of Mentha pulegium for mosquito control. Revista de Ciências Agrárias, 38, 157-167.

> J.T. Marquês,  A.S. Viana, R.F.M. de Almeida (2014) A Biomimetic Platform to Study the Interactions of Bioelectroactive Molecules with Lipid Nanodomains. Langmuir, 30 (42), 12627-12637. DOI: 10.1021/la503086a.

> A. Khmelinskaia, M. Ibarguren, R.F.M. de Almeida, D.J. López, V.A. Paixão, H. Ahayayauch, F.M. Goñi and P.V. Escribá. (2014) Changes in membrane organization upon spontaneous insertion of 2-hydroxylated unsaturated fatty acids in the lipid bilayer. Langmuir 30, 2117-2128. DOI: 10.1021/la403977f.

> R.F.M. de Almeida and E. Joly (2014) Crystallization around solid-like nanosized docks can explain the specificity, diversity and stability of membrane microdomains. Front. Plant Sci. 5, 72. DOI: 10.3389/fpls.2014.00072.

> J.T. Marquês, R.F.M. de Almeida, A.S. Viana (2014) Lipid bilayers supported on bare and modified gold - formation, characterization and relevance of lipid rafts. Electrochim. Acta 126, 139-150. DOI: 10.1016/j.electacta.2013.07.117.

> R.F.M. de Almeida, J.T. Marquês, L.C. Silva (2014) Chapter 2. Biophysics of Lipid Rafts and their Interplay with Ceramide: Studies in Model Systems and Biological Insights In: Lipid Rafts: Properties, Controversies and Roles in Signal Transduction Ed. Dan Sillence, Nova Publishers, NY, pp 21-52.

> E. Zupancic, A.C. Carreira, R.F.M. de Almeida, L.C. Silva (2014)  Biophysical Implications of Sphingosine Accumulation in Membrane Properties at Neutral and Acidic pH. J. Phys. Chem. B. 18, 4858-4866. DOI: 10.1021/jp501167f.

> A. R. Jesus, C. Dias, A. M. Matos, R. F. M. de Almeida, A. S. Viana, F. Macedo, R. T. Ribeiro, M. P. Macedo, C. Airoldi, F. Nicotra, A. Martins, E. J. Cabrita, J. Jiménez-Barbero, A. P. Rauter (2014) Exploiting the Therapeutic Potential of 8-β-D-Glucopyranosylgenistein: Synthesis, Antidiabetic Activity and Molecular Interaction with Islet Amyloid Polypeptide and Amyloid β-Peptide (1-42). J. Med. Chem., 30, 9463-9472. DOI: 10.1021/jm501069h.

> D.V. Luís, J. Silva, A.I. Tomaz, R.F.M. de Almeida, L.M.D.R.S. Martins, T.F.S. Silva, P.M. Borralho, C.M.P. Rodrigues, A.S. Rodrigues, A.J.L. Pombeiro, A.R. Fernandes. Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies. J. Biol. Inorg. Chem. 19, 787-803. DOI: 10.1007/s00775-014-1110-0.

> J. M. Caio, T. Esteves, S. Carvalho, C. Moiteiro, Vitor Félix, Azacalix[2]arene[2]triazine-based receptors bearing carboxymethyl pendant arms on nitrogen bridges: synthesis and evaluation of their coordination ability towards copper(II), Org. Biomol. Chem., 2014, 12, 589-599.

> B. Demoro, R. F. M. de Almeida, F. Marques, C. P. Matos, L. Otero, J. C. Pessoa, I. Santos, A. Rodríguez, V. Moreno, J. Lorenzo, D. Gambino, A. I. Tomaz (2013) Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism. Dalton Trans. 42, 7131–7146. DOI: 10.1039/C3DT00028A

> M.L. Martin, G. Barceló-Coblijn, R.F.M. de Almeida, M.A. Noguera-Salvà, S. Terés, M. Higuera, G. Liebisch, G. Schmitz, X. Busquets and P.V. Escribá.  (2013) The role of membrane fatty acid remodeling in the antitumor activity of 2-hydroxyoleic acid. Biochim. Biophys. Acta - Biomembr. 1828, 1405–1413. DOI: 10.1016/j.bbamem.2013.01.013.

> C. P. Matos, A. Valente, F. Marques, P. Adão, M. Paula Robalo, R. F. M. de Almeida, J. C. Pessoa, I. Santos, M. H. Garcia, A. I. Tomaz (2013) New polydentate Ru(III)-Salan complexes: synthesis, characterization, anti-tumour activity and interaction with human serum proteins. Inorg. Chim. Acta, 394, 616-626. DOI: 10.1016/j.ica.2012.09.026

> J. T. Marquês and R.F.M. de Almeida (2013) Application of Ratiometric Measurements and Microplate Fluorimetry to Protein Denaturation: An Experiment for Analytical and Biochemistry Students. J. Chem Educ. 90, 1522-1527.  http://dx.doi.org/10.1021/ed300599d

> R.F.M. de Almeida (2013) Rafts in our cells: a new role for lipids in the molecular organization of life. Atomium Culture - The Permanent Platform for European Excellence (European Commission); El País; Il Sole 24 Ore.

> M. Pinheiro, C. Nunes, J. M. Caio, C. Moiteiro, G. Brezesinski, S. Reis (2013) Interactions of N '-acetyl-rifabutin and N '-butanoyl-rifabutin with lipid bilayers: A synchrotron X-ray study, Int. J. Pharm., 453, 560-568.

> M. Pinheiro, C. Pereira-Leite, M. Arêde, C. Nunes, J. M. Caio, C. Moiteiro, J. J. Giner-Casares, M. Lúcio, G. Brezesinski, L. Camacho, S. Reis (2013) Evaluation of the Structure-Activity Relationship of Rifabutin and Analogs: A Drug-Membrane Study, ChemPhysChem, 14, 2808-2816.

> M. Pinheiro, M. Arêde, J. J. Giner-Casares, C. Nunes, J. M. Caio, C. Moiteiro, M. Lúcio, L. Camacho, S. Reis (2013) Effects of a novel antimycobacterial compound on the biophysical properties of a pulmonary surfactant model membrane, Int. J. Pharm., 450, 268-277.

> M. Pinheiro, C. Nunes, J. M. Caio, C. Moiteiro, M. Lúcio, G. Brezesinski, S. Reis (2013) The Influence of Rifabutin on Human and Bacterial Membrane Models: Implications for Its Mechanism of Action, J. Phys. Chem. B, 117, 6187-6193.

> M. Pinheiro, J. J. Giner-Casares, M. Lúcio, J. M. Caio, C. Moiteiro, J. L.F.C. Lima, S. Reis, L. Camacho (2013) Interplay of mycolic acids, antimycobacterial compounds and pulmonary surfactant membrane: a biophysical approach to disease,  Biochim. Biophys. Acta, Biomembr., 1828, 896-905.

> M. Pinheiro, M. Arêde, J. M. Caio, C. Moiteiro, M. Lúcio, S. Reis (2013) Differential Interactions of Rifabutin with Human and Bacterial Membranes: Implication for Its Therapeutic and Toxic Effects,  J. Med. Chem., 56, 417-426.

> J.T. Marquês, R.F.M. de Almeida, A.S. Viana (2012) Biomimetic membrane rafts stably supported on unmodified gold. Soft Matter 8:2007-2016.  DOI: 10.1039/C2SM06738B

> A.E.P. Bastos, H.S. Marinho, A.M. Cordeiro, A. Soure, R.F.M. de Almeida (2012) Biophysical properties of ergosterol-enriched lipid rafts in yeast and tools for their study: characterization of ergosterol/phosphatidylcholine membranes with three fluorescent membrane probes. Chem. Phys. Lipids, 165: 577-588.  DOI: 10.1016/j.chemphyslip.2012.06.002

> A.E.P. Bastos, S. Scolari, M.  Stöckl, R.F.M. de Almeida (2012)  Applications of fluorescence lifetime spectroscopy and imaging to lipid domains in vivo. Methods Enzymol.  504:57-81.  DOI: 10.1016/B978-0-12-391857-4.00003-3,

> A. I. Tomaz, T. Jakusch, T. S. Morais, F. Marques, R. F. M. de Almeida, F. Mendes, E. A. Enyedy, I. Santos, J. Costa Pessoa, T. Kiss, M. H. Garcia.  (2012) [RuII(h5-C5H5)(bipy)(PPh3)]+, a promising large spectrum antitumor agent: cytotoxic activity and interaction with Human Serum Albumin. J. Inorg. Biochem.  DOI: 10.1016/j.jinorgbio.2012.06.016

> B.M. Castro, R.F.M. de Almeida, A. Fedorov, M. Prieto (2012) The photophysics of a Rhodamine head labeled phospholipid in the identification and characterization of membrane lipid phases. Chem. Phys. Lipids, 165: 311-319.

> P.D. Vaz, C.D. Nunes, O.C. Monteiro, A.S. Viana,R.F.M. de Almeida, P. Lima (2012) O Programa CIêNCIA 2007 no CQB – das Moléculas aos Nanomateriais e à Biomedicina. Química 126, 43-50.

> M. Pinheiro, M. Lúcio, S. Reis, J. L.F.C. Lima, J. M. Caio, C. Moiteiro, M. T. Martín-Romero, L. Camacho, J. J. Giner-Casares (2012) Molecular Interaction of Rifabutin on Model Lung Surfactant Monolayers,  J. Phys. Chem. B, 116, 11635-11645.

> R. Figueiredo, D. F. Ramos, C. Moiteiro, M. A. Medeiros, M. J. M. Curto, J. C. Menezes, R. H. Pando, P. E. A. Silva, M. C. Costa (2012) Pharmacophore insights into rpoB gene mutations in Mycobacterium tuberculosis rifampicin resistant isolates, Eur. J. Med. Chem., 47, 186.

> A. I. Vicente, J. M. Caio, J. Sardinha, C. Moiteiro, R. Delgado, V. Félix (2012) Evaluation of the binding ability of tetraaza[2]arene[2]triazine receptors anchoring L-alanine units for aromatic carboxylate anions, Tetrahedron, 68, 670.

> G. Barceló-Coblijn, M. L. Martin, R. F. M. de Almeida, M. A. Noguera-Salvá, A. Marcilla-Etxenike, F. Guardiola-Serrano, A. Lüth, B. Kleuser, J. E. Halver, P.V. Escribá.  (2011) Sphingomyelin and Sphingomyelin Synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc. Natl. Acad. Sci. USA. 108:  19569-19574.

OPEN ACCESS ARTICLE

> Aresta-Branco, F., Cordeiro, A.M., Marinho, H.S., Cyrne, L., Antunes, F., and de Almeida, R.F.M. Gel domains in the plasma membrane of Saccharomyces cerevisiae: highly ordered. sphingolipid-enriched, ergosterol-free lipid rafts. J. Biol. Chem. 286: 5043-5054.

 doi:10.1074/jbc.M110.154435

> Marquês, J.M., Viana, A.S., and de Almeida, R.F.M. Ethanol effects on binary and ternary supported lipid bilayers with gel/fluid domains and lipid rafts. Biochim. Biophys. Acta - Biomembr. 1808: 405-414. doi:10.1016/j.bbamem.2010.10.006

> Castro, B.M., de Almeida, R.F.M., Goormaghtigh, E., Fedorov, A., Prieto, M. Organization and dynamics of Fas transmembrane domain in raft membranes and modulation by ceramide. Biophys. J. 101:1632-1641.

> Vicente, M.I., Costa, P.F., and Lima, P.A. Galantamine inhibits slowly inactivating K+ currents with a dual dose-response relationship in differentiated N1E-115 cells and in CA1 neurones. Eur. J. Pharmacol. 634: 16-25.

> Lima P.A., Alves, F.M., Vicente M.I., Bastos A.E., Auger C., Ogden D., Costa P.F. (2010) ERG K+ currents in hippocampal CA1 pyramidal neurones and N1E-115 neuroblastoma cells. FENS Abstr. 5:013.23.

> Castro, B.M., Silva, L.C., Fedorov, A., de Almeida, R.F.M., and Prieto, M. (2009) Cholesterol-rich fluid membranes solubilize ceramide-domains. Implications for the structure and dynamics of mammalian intracellular and plasma membrane. J. Biol. Chem. 284: 22978 - 22987. Reprint request

> Silvia Scolari, Stephanie Engel, Nils Krebs, Anna Pia Plazzo, Rodrigo F.M. De Almeida, Manuel Prieto, Michael Veit and Andreas Herrmann (2009) Lateral Distribution of the Transmembrane Domain and Cytoplasmic Tail of Influenza Virus Hemagglutinin revealed by Time-resolved Fluorescence Imaging. J. Biol. Chem.  284:15708-15716.

> Guillén, J., de Almeida, R.F.M., Prieto, M., and Villalaín, J. (2009) Interaction of a peptide corresponding to the loop domain of the S2 SARS-CoV virus protein with model membranes. Mol. Membr. Biol. 26: 236-248.

> Pedroso, N., A. C. Matias, L. Cyrne, F. Antunes, C. Borges, R. Malhó, R. F. M. de Almeida, E. Herrero, H. S. Marinho (2009) Modulation of plasma membrane lipid profile and microdomains by H2O2 in Saccharomyces cerevisiae. Free Rad. Biol. Med. 46:289-298.

> de Almeida, R.F.M., Loura, L.M. S., and Prieto, M. (2009) Membrane lipid domains and rafts: current applications of fluorescence lifetime spectroscopy and imaging. Chem. Phys. Lipids 157: 61-77.  PDF Available

> Loura, L.M.S., de Almeida, R.F.M., Silva, L.C., and Prieto, M. (2009) FRET Analysis of Domain Formation and Properties in Complex Membrane Systems. Biochim. Biophys. Acta Biomembr. 1788: 209-224.

> Sandra N. Pinto, Liana C. Silva, Rodrigo F.M. de Almeida, and Manuel Prieto. (2008) Membrane domain formation, interdigitation and morphological alterations induced by the very long chain asymmetric nervonoyl-ceramide. Biophys. J. 95:2867-2879.

> Guillén, J., de Almeida, R.F.M., Prieto, M. and Villalan, J. (2008) Structural and dynamic characterization of the interaction of the putative fusion peptide of the S2 SARS-CoV virus protein with lipid membranes. J. Phys. Chem. B. 112:6997-7007.

> Holt, A., de Almeida, R. F. M., Nyholm, T. K. M., Loura, L. M. S., Daily, A. E., Stahorst, R. W. H. M., Rijkers, D. T. S., Koeppe II, R. E., Prieto, M., and Killian, J. A. (2008) Is there a Preferential Interaction between Cholesterol and Tryptophan Residues in Membrane Proteins? Biochemistry 47:2638-2649.

> Lima PA, Vicente MI, Alves FM, Dionísio JC and Costa PF  (2008). Insulin increases excitability via a dose-dependent dual inhibition of voltage-activated K+ currents in N1E-115 neuroblastoma cells. Eur. J. Neurosci.  27:20192032.

> Castro, B. M., de Almeida, R. F. M., Silva, L. C., Fedorov, A., Prieto, M. (2007) Formation of ceramide/sphingomyelin gel domains in the presence of an unsaturated phospholipid. A quantitative multiprobe approach. Biophys. J. 93:1639-1650. Reprint request

> de Almeida, R. F. M., Borst, J. W., Fedorov, A., Prieto, M. and Visser, A. J. W. G. (2007) Complexity of lipid domains and rafts in giant unilamellar vesicles revealed by combining imaging, microscopic and macroscopic time-resolved fluorescence. Biophys. J. 93:539-553. Reprint request

> Silva, L. C., de Almeida, R. F. M., Castro, B. M., Fedorov, A. and Prieto, M. Ceramide-domain formation and collapse in lipid raft membranes: membrane reorganization induced by an apoptotic lipid. (2007) Biophys. J. 92:502-516.

> Silva, L., de Almeida, R. F. M., Fedorov, A., Matos, A. P. A., and Prieto, M. (2006) Ceramide-platform formation and induced biophysical changes in a fluid phospholipid membrane. Mol. Membr. Biol. 23, 137-148. Reprint request

> de Almeida, R. F. M., Loura, L. M. S., A. Fedorov, and Prieto, M. (2005) Lipid rafts have different size depending on membrane composition: a time-resolved fluorescence resonance energy transfer study. J. Mol. Biol. 346, 1109-1120. PDF Available

> de Almeida, R. F. M., Loura, L. M. S., Prieto, M., Watts, A., Fedorov, A., and Barrantes, F. J. (2004) Cholesterol modulates  the organization of the gM4 transmembrane domain of the muscle nicotinic acetylcholine receptor. Biophys. J. 86, 2261-2272.

> de Almeida, R. F. M., Fedorov, A., and Prieto, M. (2003) Sphingomyelin / phosphatidylcholine / cholesterol phase diagram: boundaries and composition of lipid rafts. Biophys. J. 85, 2406-2416.   PDF Available

> de Almeida, R. F. M., Loura, L. M. S., and Prieto, M. Non-equilibrium phenomena in the phase separation of a two-component lipid bilayer. (2002) Biophys. J. 82, 823-834.

> Lima PA, Marrion NV (2007). Mechanisms underlying activation of the slow AHP in rat hippocampal neurons. Brain Res. 1150:74-82.

> Loan D.J., Lima P.A.,  Marrion NV (2007). Co-assembly of N-type Ca2+ and BK channels underlies functional coupling in rat brain. J. Cell Science. 120:985-995

> Mathger L.M., Collins TF and  Lima PA (2004). The role of muscarinic receptors and intracellular Ca2+ in the spectral reflectivity changes of squid iridophores. J. Exp. Biol. 207:1759-69

> Prole D.L., Lima P.A. and Marrion NV (2003). Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons. J. Gen. Physiol. 122:775-93.

> Lima P.A., Nardi G., Brown E.R. (2003). AMPA/kainate and NMDA-like glutamate receptors at the chromatophore neuromuscular junction of the squid: role in synaptic transmission and skin patterning. Eur J Neurosci. 17:507-16.

> Dajas-Bailador, F. A., Lima P. A. and Wonnacott., S. (2000). The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca2+ dependent mechanism. Neuropharmacology. 39:2799-2807.

> Benech JC, Lima P.A., Sotelo JR & Brown ER (2000) Luminal calcium in synaptosomes isolated from the squid optic lobe. J. Neurosci. Res. 62: 840-6